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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

da Costa M, Rothenberg SP, Sadasivan E, Regec A, Qian L

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This unfortunately common ailment includes tension-type headaches, cluster headaches, and migraines